Interactome

iRhominteractome
Written By Gloomy Court

To better understand the function, regulation, dynamics and assembly of the iRhom-ADAM17 complex, we investigate the interactome of iRhom2 by mass spectrometry. Through this proteomics approach, we have already identified several new binding partners, which are involved in vesicle fusion and thus in intracellular transport [1].

 

References

[1] Düsterhöft, S., et al. (2021). "The iRhom homology domain is indispensable for ADAM17-mediated TNFalpha and EGF receptor ligand release." Cell Mol Life Sci 78(11):5015-5040. DOI: 10.1007/s00018-021-03845-3

Gloomy Court
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Structure-Function Analysis of iRhoms
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Spatio-temporal regulation of the iRhom-ADAM17 complex