MaPIN

Mapping of Protein Interaction Networks

Recent advances in technology have greatly improved our ability to study genes and proteins in cells, but understanding how these discoveries affect biological processes remains a challenge. Many proteins function in intricate clusters and networks where protein functions and their signals cross and modulate each other, making it essential to unravel these interactions to better understand complex physiological and pathological conditions.

AI tools such as AlphaFold, which predicts protein structures, have revolutionised our understanding of protein function. Building on this, we have developed MaPIN (Mapping of Protein Interaction Networks), a computational tool designed to analyse protein interactions in a variety of biological contexts. By integrating data from protein studies, gene expression and molecular mutations, MaPION helps to identify critical protein networks and interaction sites.

What sets MaPION apart is its ability to look beyond established pathways and uncover novel interactions within these complex networks. This approach provides deeper insights into the underlying mechanisms of different physiological processes and disease states, potentially revealing new therapeutic targets.

Cluster Biology of Inflammation

Like the iRhom-ADAM17 complex, proteins are often part of larger functional complexes. When analysing these complexes, one has to take into account that these complexes are not static, but rather change dynamically depending on the cellular milieu and functional requirements. Therefore, we tend to consider the target proteins in our studies as parts of larger molecular clusters.